MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation
Current approaches to study glycosylation of polyclonal human immunoglobulins G (IgG) usually imply protein digestion or glycan release.While these approaches NES allow in-depth characterization, they also result in a loss of valuable information regarding certain subclasses, allotypes and co-occuring post-translational modifications (PTMs).Unfortu